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CREATE A MORE REPRESENTATIVE IN VITRO MODEL TO INCREASE RESEARCH AND DEVELOPMENT SUCCESS

Nortis’ versatile microfluidic technology enables researchers to engineer a wide range of three-dimensional tissue microenvironments.

MICROFLUIDIC CHIPS AND SUPPORTING PERFUSION PLATFORM

About the size of a credit card, Nortis' unique microfluidic chips can be used to grow tissue microenvironments by seeding cells into tubular voids within extracellular matrix gels. The chip design offers the flexibility to generate a variety of tissue architectures based on cell types and matrix materials selected.

Small, portable perfusion platforms house the disposable chips and supporting media and collection reservoirs. Three-shelved docking stations that reside in a standard tissue culture incubator increase experimental throughput and flexibility by enabling up to twelve independent experiments to be run at a time. Perfusion through both the tissue lumen and surrounding extralumenal space allow physico-chemical gradients to be created and perfusion fluids and cells to be collected for downstream analysis. Each docking station shelf can easily be removed and the small perfusion platform/chip assemblies accommodate easy transport between the cell culture incubator, laminar flow hood, and microscope stage.


PRECISE CONTROL OF FLUIDIC FLOW

A key element of Nortis' technology is the ability to subject the tissues to fluid flow directly through the vessel lumen, which enables:

  • Creation of vasculature and other tubular tissues
  • Delivery of test compounds via the perfusate
  • Exposure to shear and flow forces that are present in the body
  • Independent perfusion through the vessel and matrix compartments

The entire Nortis system fits inside a standard tissue culture incubator.