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2020

Predicting tubular reabsorption with a human kidney proximal tubule tissue-on-a-chip and physiologically-based modeling. Courtney Sakolish, Zunwei Chen, Chimeddulam Dalaijamts, Kusumica Mitra, Yina Liu, Tracy Fulton, Terry L.Wade, Edward J. Kelly, Ivan Rusyn, Weihsueh A. Chiua. Toxicology in Vitro 63, 2020. doi:10.1016/j.tiv.2019.104752

An Improved Vascularized, Dual-Channel Microphysiological System Facilitates Modeling of Proximal Tubular Solute SecretionAlenka Chapron, Brian D. Chapron, Dale W. Hailey, Shih-Yu Chang, Tomoki Imaoka, Kenneth E. Thummel, Edward Kelly, Jonathan Himmelfarb, Danny Shen, Catherine K. Yeung. ACS Pharmacol. Transl. Sci. 2020. doi:10.1021/acsptsci.9b00078

Tissue Chips in Space—Challenges and Opportunities. Catherine K. Yeung, Paul Koenig, Stefanie Countryman, Kenneth E. Thummel, Jonathan Himmelfarb and Edward J. Kelly. Clin Transl Sci13, 8–10; 2020. doi:10.1111/cts.12689

2019

Translational Assessment of Drug- Induced Proximal Tubule Injury Using a Kidney Microphysiological System. Christian Maass, Nathan B. Sorensen, Jonathan Himmelfarb, Edward J. Kelly, Cynthia L. Stokes and Murat Cirit. Pharmacometrics Syst. Pharmacol. 8, 316–325. 2019. doi:10.1002/psp4.12400

Emerging In Vitro Systems to Screen and Predict Drug-Induced Kidney Toxicity. Tom T.G. Nieskens and  Anna-Karin Sjögren. Semin Nephrol. 39(2):215-226. 2019. doi:10.1016/j.semnephrol.2018.12.009

Kidneys on Chips: Emerging Technology for Preclinical Drug Development.  Catherine K. Yeung and Jonathan Himmelfarb. CJASN 14(1) 144-146; 2019. doi:10.2215/CJN.06690518

2018

Human kidney on a chip assessment of polymyxin antibiotic nephrotoxicityElijah J. Weber, Kevin A. Lidberg, Lu Wang, Theo K. Bammler, James W. MacDonald, Mavis J. Li, Michelle Redhair, William M. Atkins, Cecilia Tran, Kelly M. Hines, Josi Herron, Libin Xu, Maria Beatriz Monteiro, Susanne Ramm, Vishal Vaidya, Martti Vaara, Timo Vaara, Jonathan Himmelfarb, and Edward J. Kelly. JCI Insight 3(24):e123673; 2018. doi:10.1172/jci.insight.123673

Introducing an automated high content confocal imaging approach for Organs-on-ChipsSamantha Peel, Adam M. Corrigan, Beate Ehrhardt, Kyung-Jin Jang, Pedro Caetano-Pinto, Matthew Boeckeler, Jonathan E. Rubins, Konstantia Kodella, Debora B. Petropolis, Janey Ronxhi, Gauri Kulkarni, Alison J. Foster, Dominic Williams, Geraldine A. Hamilton, and Lorna Ewart. Lab on a chip 3. 2019. doi:10.1039/C8LC00829A

A 3D Human Renal Cell Carcinoma-on-a-Chip for the Study of Tumor AngiogenesisChris P.Miller, Connor Tsuchida, Ying Zheng, Jonathan Himmelfarb, Shreeram Akilesh. Neoplasia 20(6). 2018. doi:10.1016/j.neo.2018.02.011

2017

Human liver-kidney model elucidates the mechanisms of aristolochic acid nephrotoxicityShih-Yu Chang, Elijah J. Weber, Viktoriya S. Sidorenko, Alenka Chapron, Catherine K. Yeung, Chunying Gao, Qingcheng Mao, Danny Shen, Joanne Wang, Thomas A. Rosenquist, Kathleen G. Dickman, Thomas Neumann, Arthur P. Grollman, Edward J. Kelly, Jonathan Himmelfarb, and David L. Eaton. JCI Insight 2(22):e95978; 2017. doi:10.1172/jci.insight.95978

Characterization of rat or human hepatocytes cultured in microphysiological systems (MPS) to identify hepatotoxicityShih-Yu Chang, Jenna L.Voellinger, Kirk P. Van Ness, Brian Chapron, Rachel M. Shaffer, Thomas Neumann, Collin C.White, Terrance J. Kavanagh, Edward J. Kelly, David L. Eaton. Toxicology in vitro 40:170-183; 2017. doi:10.1016/j.tiv.2017.01.007

Organ-on-a-chip devices advance to marketBoyang Zhang and Milica Radisic. Lab on a Chip 14; 2017. doi:10.1039/C6LC01554A

Microphysiological Systems to Assess Nonclinical Toxicity
Kirk P. Van Ness, Shih‐Yu Chang, Elijah J. Weber, Danielle Zumpano, David L. Eaton, Edward J. Kelly. Current Protocols in Toxicology 73(1); 2017. doi:10.1002/cptx.27

Current State of In vitro Cell-Based Renal ModelsElnaz Gozalpour, Katherine S. Fenner. Current Drug Metabolism 19 (4). 2018. doi:10.2174/1389200219666180119115133

Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle. Lawrence Vernetti, Albert Gough, Nicholas Baetz, Sarah Blutt, James R. Broughman, Jacquelyn A. Brown, Jennifer Foulke-Abel, Nesrin Hasan, Julie In, Edward Kelly, Olga Kovbasnjuk, Jonathan Repper, Nina Senutovitch, Janet Stabb, Catherine Yeung, Nick C. Zachos, Mark Donowitz, Mary Estes, Jonathan Himmelfarb, George Truskey, John P. Wikswo & D. Lansing Taylor. Sci Rep 7, 42269; 2017. https://doi.org/10.1038/srep42296

2016

Development of a microphysiological model of human kidney proximal tubule functionElijah J. Weber, Alenka Chapron, Brian D. Chapron, Jenna L. Voellinger, Kevin A. Lidberg, Catherine K. Yeung, Zhican Wang, Yoshiyuki Yamaura, Dale W. Hailey, Thomas Neumann, Danny D. Shen, Kenneth E. Thummel, Kimberly A. Muczynski, Jonathan Himmelfarb, Edward J. Kelly. Kidney International 90(3):627-637; 2016. doi:10.1016/j.kint.2016.06.011

A human liver microphysiology platform for investigating physiology, drug safety, and disease modelsLawrence A Vernetti, Nina Senutovitch, Robert Boltz, Richard DeBiasio, Tong Ying Shun, Albert Gough, D Lansing Taylor. SEBM 241(1); 2016. doi:10.1177/1535370215592121

Liver and Kidney on Chips: Microphysiological Models to Understand Transporter FunctionS.Y. Chang, E.J. Weber, K.P. Van Ness, D.L. Eaton, E.J. Kelly. Clinical Pharmacology and Therapeutics 100(5):464-478; 2016. doi:10.1002/cpt.436

Maintenance of vascular integrity by pericytes is essential for normal kidney functionDario R. Lemos, Graham Marsh, Angela Huang, Gabriela Campanholle, Takahide Aburatani, Lan Dang, Ivan Gomez, Ken Fisher, Giovanni Ligresti, Janos Peti-Peterdi, and Jeremy S. Duffield.  Am J Physiol Renal Physiol 311: F1230 –F1242; 2016. doi:10.1152/ajprenal.00030.2016

A Quantitative Approach to Screen for Nephrotoxic Compounds In Vitro.
Melanie Adler, Susanne Ramm, Marc Hafner, Jeremy L. Muhlich, Esther Maria Gottwald, Elijah Weber, Alenka Jaklic, Amrendra Kumar Ajay, Daniel Svoboda, Scott Auerbach, Edward J. Kelly, Jonathan Himmelfarb and Vishal S. Vaidya
JASN 27 (4) 1015-1028; 2016. doi:10.1681/ASN.2015010060

2015

Fluorescent Protein Biosensors Applied to Microphysiological SystemsNina Senutovitch, Lawrence Vernetti, Robert Boltz, Richard DeBiasio, Albert Gough, D Lansing Taylor. Exp Biol Med 240(6): 795–808; 2015. doi:10.1177/1535370215584934

2014

Tissue-engineered microenvironment systems for modeling human vasculatureAnna Tourovskaia, Mark Fauver, Gregory Kramer, Sara Simonson, Thomas Neumann. SEBM 239(9); 2014. doi:10.1177/1535370214539228

2013 

Innovations in preclinical biology: ex vivo engineering of a human kidney tissue microperfusion system. Edward J Kelly, Zhican Wang, Jenna L Voellinger, Cathy K Yeung, Danny D Shen, Kenneth E Thummel, Ying Zheng, Giovanni Ligresti, David L Eaton, Kimberly A Muczynski, Jeremy S Duffield, Thomas Neumann, Anna Tourovskaia, Mark Fauver, Greg Kramer, Elizabeth Asp & Jonathan Himmelfarb. Stem Cell Res Ther 4, S17; 2013. doi:10.1186/scrt378