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Technology

The Nortis ParVivo microfluidic devices are the industry’s most proven platform for growing cells into 3D human tissues.

ParVivo Chips

Nortis' unique microfluidic chips grow microscopic organ models by seeding cells into tubular voids within extracellular matrix gels.  Three dimensional tubules are fully surrounded by matrix allowing cells to self-organize into in-vivo like structures.  The chip design offers the flexibility to generate a variety of tissue architectures based on cell types and matrix materials selected.  Multiple chip designs are available allowing to streamline throughput or create more complex micro-physiological environments. Each chip supports a wide range of readouts including: fluorescent microscopy, effluent analysis, permeability studies, histology, and gene expression analysis.

ParVivo Perfusion System

The ParVivo perfusion platforms each house 1 ParVivo chip and up to six supporting media reservoirs. Three-shelved docking stations that reside in a standard tissue culture incubator enable up to 36 independent experiments to be run at a time. Perfusion through both the tissue lumen and surrounding extralumenal space allow physico-chemical gradients to be created and perfusion fluids and cells to be collected for downstream analysis. Each docking station shelf or an individual perfusion platform can easily be removed using the sealed quick connect fittings allowing easy transport between the cell culture incubator, biosafety cabinet, and microscope stage.

The ParVivo incubator gas pump powers the system and provides precise control of flow rates.  The pump recirculates incubator air maintaining your specific gas conditions without any additional consumables.  This precise flow control enables:

  • Creation of vasculature and other tubular tissues
  • Delivery of test compounds via the perfusate
  • Exposure to shear and flow forces that are present in the body
  • Independent perfusion through the vessel and matrix compartments

 

A wide range of tissue microenvironments can be created in the disposable microfluidic chips.

The perfusion platforms allow easy connection between the chips and associated media and collection reservoirs.

The incubator gas pump pressurizes air from inside the incubator to pneumatically drive fluid through the system.

The Nortis system fits inside a standard tissue culture incubator.